Transmembrane signaling protocols

LKB1 in transmembrane receptor signaling

Signal processing and integration is critical in physiology, as it is in disease conditions. Conversion of extracellular signals into appropriate biological responses by cell membrane receptors, and subsequent extinction of signaling events is critical to cellular hemostasis. Defective trafficking, internalization or degrardation of transmembrane receptors (TMRs) result in perturbed activation ...

Internet QoS Signaling Protocols

The aim of this paper is to survey the main Internet Quality of Service signaling protocols. We discuss some classification criteria and design issues.

Active Signaling Protocols

Signaling by Transmembrane Proteins Shifts Gears

The HAMP domain is present in a large number of transmembrane proteins in prokaryotes including histidine kinases, adenylyl cyclases, chemotaxis receptors, and phosphatases. In this issue of Cell, Hulko et al. (2006) report the NMR structure of a HAMP domain and present data suggesting that it transduces signals through a simple rotation of its four-helix parallel coiled coil.

Transmembrane sequences are determinants of immunoreceptor signaling.

To investigate structural features critical for signal initiation by Ag-stimulated immunoreceptors, we constructed a series of single-chain chimeric receptors that incorporate extracellular human Fc epsilonRIalpha for IgE binding, a variable transmembrane (TM) segment, and the ITAM-containing cytoplasmic tail of the TCR zeta-chain. We find that functional responses mediated by these receptors a...